Kuo Wei-pai obtained his Bachelor of Arts degree from Beijing Teachers' College (now Capital Normal University) in 1922. In 1927 he received Master of Arts in Political Science from Columbia University, Doctor of Juridical Science from New York University in 1930.
Mr. Kuo was a lecturer of the National Kwangtung University (later National Sun Yat-sen University), Taiwan, during 1922-1924. He was a chief of the Secretariat Division and concurrently secretary of the Young Men's Department, Central Kuomintang Execuctive Committee, in 1924-1926. Kuo Wei-pai served as an editor-in-chief, Young China Morning Post, San Francisco, in 1926. From 1930 to 1931 Mr. Kuo acted as a lecturer, National Normal University, Peking. He was a member of the Planning Committee of Extraordinary Convention, Central Kuomintang Executive Committee in 1931.
Between 1931 and 1932 Kuo Wei-pai held the position of a professor at School of Law, Sun Yat-Sen University, Guangzhou. He was a chief of the General Affiairs Department, Bureau of Foreign Trade, Ministry of Industry and member of the China Commission, International Exposition, Chicago, in 1932-1934.
Later he acted as a Vice-Director of the Bureau of Foreign Trade, Ministry of Industry and was a member of the Commercial Treaty Commission, Ministry of Industry and then managing director of the The Nation Monthly Association.