Originally destined for a career in the Church, he instead chose to study law, and entered the Middle Temple in 1784.
He served as Chief Justice of the Common Pleas from 1824 to 1829. He became a student at Wadham College, Oxford at the age of 15, but left at 17 without a degree. Best was called to the bar in 1789 and established a successful legal practice.
In 1802 he was elected to parliament for Petersfield as a Whig, a seat he held until 1806.
After joining the Tories, he sat for Bridport from 1812 to 1817 and then represented Guildford from 1818 to 1819. In 1813 Best was appointed Solicitor-General to the Prince of Wales, which he remained until 1816, and was then Attorney-General to the Prince of Wales from 1816 to 1818.
The following year he was made a Judge of the Common Pleas and knighted. Best was admitted to the Privy Council in 1824 and appointed Chief Justice of the Common Pleas, in which post he remained until 1829.
The latter year Best was raised to the peerage as Baron Wynford, of Wynford Eagle in the County of Dorset.
Lord Wynford later served as a Deputy Speaker of the House of Lords. Despite his earlier affiliation with the Whigs, he became known as an ardent Tory, and vigorously opposed the 1832 Reform Acting. Lord Wynford suffered from gout for many years, and was carried into the House of Lords in an arm-chair, in which he was also allowed to address the rest of the house.
However, he was later forced to retire from public life due to his illness.
They lived together at Wynford House at Wynford Eagle in Dorset where they raised ten children. Lord Wynford"s daughter, Grace Anne Best, married Philip Lake Godsal, the grandfather of Philip Thomas Godsal.
4th United Kingdom Parliament. 5th United Kingdom Parliament. 6th United Kingdom Parliament.