Lewis was the second son of Sir Edward Lewis, a courtier, and his wife Lady Anne Sackville, daughter of Robert Sackville, 2nd Earl of Dorset and widow of Edward, Lord Beauchamp. His father was of The Van, Glamorgan and Edington Priory, Wiltshire and died in 1630.
Jesus College.
Lewis matriculated at Jesus College, Oxford on 12 October 1638, aged 14. Lewis was commissioner for assessment for Oxfordshire from January 1660 and was commissioner of militia fr Oxfordshire in March 1660. He was a Justice of the Peace from March 1660 until his death.
He was Deputy Lieutenant from August 1660.
Lewis died at the age of about 35. The marriage enabled him to buy an estate at Bletchington in 1656 for £10,000.
In 1660, he was elected Member of Parliament for Devizes.
