Worthington, William was born on August 3, 1847 in Cincinnati, Ohio, United States. Son of Vachel and Julia (Wiggins) Worthington.
Bachelor of Arts, Harvard, 1867, A.M., 1870.
Practiced in Cincinnati, since 1869. Partnership with late Drausin Wulsin, as Wulsin & Worthington, 1877-1882, with Edward W. Strong, as Worthington & Strong, 1904-1914, later Worthington, Strong, Settinius & Hollister. Judge Superior Court of Cincinnati, 1882-1883.
Trustee to rebuild Hamilton County Court House, 1884-1886. Delegate Ohio State Constitutional Convention, 1912. Director and general counsel Little Miami Railroad Company Trustee University of Cincinnati, 1883-1888.
Trustee Cincinnati Museum Association, Cincinnati Music Hall Association, Spring Grove Cemetery, Colored Industrial School.