Subbarao discovered many more antibiotics for a wide range of cures, other than the already discovered penicillin and streptomycin. His research led him to the discovery of polymyxin which is still used in cattle-feed. This led to laying the foundation for the isolation of vitamin B9, the antipernicious anemia factor, based on the work conducted by Lucy Wills in 1945.
Background
He was born to a Telugu Niyogi Brahmin family in Bhimavaram of the Old Madras Presidency, now in West Godavari District, Andhra Pradesh. He passed through a traumatic period in his schooling at Rajahmundry (due to the premature death of close relations by disease) and eventually matriculated in his third attempt from the Hindu High School, Madras. He passed the Intermediate Examination from the Presidency College and entered the Madras Medical College where his education was supported by friends and Kasturi Suryanarayana Murthy, whose daughter he later married. Following Gandhi's call to boycott British goods he started wearing khadi surgical dress; this incurred the displeasure of M. C. Bradfield, his surgery professor. Consequently, though he did well in his written papers, he was awarded the lesser LMS certificate and not a full MBBS degree.
Career
At Lederle, Subbarao discovered many more antibiotics for a wide range of cures, other than the already discovered penicillin and streptomycin. His research led him to the discovery of polymyxin which is still used in cattle-feed. This led to laying the foundation for the isolation of vitamin B9, the antipernicious anemia factor, based on the work conducted by Lucy Wills in 1945. He applied different inputs given by Dr. Sidney Farber to develop an anti-cancer drug Methotrexate, one of the first cancer chemotherapy agents, which is still used worldwide. He was also credited with the discovery of drug Hetrazen, a cure for filariasis at Lederle. Today, this drug is the most widely used medicine for treating filariasis, including World Health Organization. Under his directorship, Benjamin Duggar gave birth to his discovery of the world's first tetracycline antibiotic, Aureomycin in the same year. This resulted as one of the largest distributed scientific experiments till date with American soldiers being asked to collect soil samples during World War II and deposit them at Lederle Laboratories for anti-bacterial agents from natural soil fungi. Another medicine that he discovered was Isonicotinic acid Hydrazide, an effective cure for tuberculosis.