Yiannis studied at the University of Tennessee in Knoxville, Tennessee, United States. In 1994 he became a Doctor of Philosophy.
Yiannis served at the Greek Air Force in Volos, Greece from 1995 to 1996. In two year he worked as an assistant professor of the University of Aegean in Mytilene, Greece. He worked there until 2006. In 2007 he worked as an associate professor.
Yiannis married to Maria Minioti on June 28, 1998. They have a child: George Y. Matsinos.