Career
At the early age of twenty-five Tzahalon was requested by Samuel Yafeh, a rabbi of Constantinople, to decide a difficult and complicated problem which had been referred to himself and he corresponded with most of the authorities of his time, one of his chief antagonists being Moses Galante (the Elder). Tzahalon was the author of a commentary on the Book of Esther, entitled Lekach Tov (Safed, 1577). He likewise wrote a commentary on the Abot de-Rabbi Natan, entitled Magen Avot, which is still extant in manuscript.
In his preface to this latter work Tzahalon terms himself Yom-Tov ben Moses ha-Sefardi, whence it is clear that the family came originally from Spain, although it is not known when it emigrated or where Tzahalon was born.