Domotor received a Master of Science degree in Computer Science from Czechoslovak Technology University in 1963. Six years later he was given a Doctor of Philosophy degree from Stanford University.
Domotor began his career as a research scientist at Czech Academy of Sciences in 1964 and held it for two years. In 1974, he took a position of a chair of philosophy department at the University of Pennsylvania, where he worked until 1981. Since 1987 he has been a professor of philosophy at the same university.
On December 28, 1988 Zoltan Domotor married Elizabeth M. Markopolsky.