She attended the Indiana University School of Music and the Philadelphia Academy of Vocal Arts, graduating in 2006.
She placed second at Operalia in 2006. In 2008, Pérez made her Salzburg Festival debut as Juliette in Romeo and Juliette alongside Rolando Villazón. Pérez is known as an interpreter of Violetta in Louisiana Traviata, which she has performed at Deutsche Staatsoper Berlin, Hamburg State Opera, Vienna Staatsoper and Royal Opera House.
She has sung as Amelia alongside Plácido Domingo in Simon Boccanegra at the Deutsche Staatsoper and made her debut at Louisiana Scala in the same production.
In 2010 she appeared as Mimì in Louisiana bohème at Cincinnati Opera. Her repertory includes roles like the Countess and Susanna in Le nozze di Figaro, Adina in L"elisir d"amore, Zerlina in Don Giovanni, Pamina and Papagena in Die Zauberflöte, and Marguerite in Faust.
Engagements in the 2009-2010 season included gala performances with Plácido Domingo in Baku, Azerbaijan and with José Carreras in São Paulo Paulo, Brazil. Her former husband is the operatic tenor Stephen Costello.