Having previously worked in television production, Osho turned to acting in 2003. By 2006, she had decided to go into stand-up comedy. Osho spent a number of years working as a receptionist by day, while perfecting her stand-up comedy routine in the evenings.
In 2006, Osho starred as Alma in Dael Orlandersmith"s drama Yellowman at Liverpool"s Everyman Theatre.
Other theatre work includes a critically acclaimed performance in the title role of Medea (Barons Court Theatre, 2005), Amanda in Cigarettes, Coffee and Paranoia (King"s Head Theatre, 2005) and Zimbabwean exile Faith in the devised piece Qabuka (Oval House Theatre, 2005). Osho"s television roles include Lin Colvin in Casualty, Adeola Brooker in Doctors, Doctor Rogers in Football players" Wives: Extra Time and Angela Parker in Sea of Souls.
She has also appeared in Waking the Dead, EastEnders and Night and Day and Russell Brand and Friends for Channel 4. In 2007, Osho wrote the comedy Computer Society of India: Nigeria, in production for British Broadcasting Corporation Three.
Osho has performed at various comedy clubs and festivals across Britain, including: Jongleurs, the Comedy Store, the Reading Festival, the Pleasance Dome, the Chuckle Club, the Leicester Festival (Summer Sundae), the Comedy Café, the Shoreditch Comedy Festival, Comedy Camp and the Hackney Empire.
Osho co-hosted Tonightly on Channel 4 and appeared in an E4 pilot, The Andi O Show. On 26 February 2011, Osho participated in Let"s Dance for Comic Relief, performing a dance routine to Michael Jackson"s "Bad". Despite positive comments from the judges, she did not progress to the final round after a public vote.
Osho also takes an occasional presenting role for the comedy club section on British Broadcasting Corporation Radio 4 Extra
On 19 June 2012, Osho made her debut in medical drama Holby City as medical student Barbara Alcock for three episodes.
In July 2014, she appeared in Finding Carter as Susan Sherman. She presents Supershoppers with Anna Richardson on Channel 4.
lieutenant began on 1 February 2016.
Osho is also a playwright and one of the founding members of the London writers" group, Vowel Movement.