Career
Anna was the third child of Grand Duke Francesco and Archduchess Joanna. She had two surviving sisters, Eleanor, Duchess of Mantua, and Marie, Queen of France. Francesco betrothed Anna in 1578 to Charles, Margrave of Burgau, son of Ferdinand II, Archduke of Austria (a brother of her mother).
A portrait of Anna was sent to the Archduke.
Anna"s father even asked permission in 1579 for the marriage from Philip II of Spain, who was one of the most powerful rulers of the time. lieutenant is possible that after the failed negotiations, Francesco set up further ones for a marriage for Anna to Charles Emmanuel I, Duke of Savoy.
But these negotiations were also called off and Charles Emmanuel was soon married to Infanta Catherine Michelle of Spain, daughter of King Philip. Anna soon became sickly and was dying.