Arthur Beck Beck Pardee

Background

Pardee, Arthur Beck was born on July 13, 1921 in Chicago, Illinois, United States. Son of Charles A. and Elizabeth B. (Beck) Pardee.

Education

Bachelor of Science, University California, Berkeley, 1942. Master of Science, California Institute of Technology, 1943. Doctor of Philosophy, California Institute of Technology, 1947.

Doctor (honorary), University Paris, 1993.

Career

One biographical portrait begins "Among the titans of science, Arthur Pardee is especially intriguing." There is hardly a field of molecular biology that is not affected by his work, which has advanced our understanding through theoretical predictions followed by insightful experiments. He is perhaps most famous for his part in the "experiment" of the late 1950s, which greatly helped in the discovery of messenger Ribonucleic acid. He is also well known as the discoverer of the restriction point, in which a cell commits itself to certain cell cycle events during the G1 cycle. He has done a great deal of work on tumor growth and regulation, with a particular focus on the role of estrogen in hormone-responsive tumors.

And he is also well known for the development of various biochemical research techniques, most notably the differential display methodology, which is used in examining the activation of genes in cells.

More recently he has championed the acceptance and adoption of the conceptual review as a valuable approach to unearthing new knowledge from the enormous stores of information in the scientific literature. Pardee received his Bachelor of Science degree from the University of California, Berkeley in 1942 while his Masters (1943) and Doctor of Philosophy (1947) degrees were earned at the California Institute of Technology under the mentorship of Linus Pauling, who he considered to be the greatest chemist of the 20th century.

Pardee did postdoctoral work at the University of Wisconsin–Madison before returning to Berkeley as an instructor in biochemistry in 1949. In the 1950s, he was on a sabbatical with Francois Jacob and Jacques Monod in Paris.

In 1961 Pardee became Professor in Biochemical Sciences at Princeton University while in 1975 he moved to Boston to become Professor of Biological Chemistry and Molecular Pharmacology at the Dana-Farber Cancer Institute and Harvard Medical School as well as Chief for the Division of Cell Growth and Regulation at the Dana-Farber Cancer Institute.

Pardee became an emeritus professor at Dana-Farber in 1992. While on sabbatical with Francois Jacob and Jacques Monod, Pardee was involved in an experiment that became known as The experiment, and later work with his student Monica Riley showed that protein synthesis from a gene could begin almost as soon as the gene entered an East.coli cell. Prior hypotheses around the translation of genetic information into proteins had focused on ribosomes, which turned over too slowly to enable the rapid synthesis seen in This led to the hypothesis that yet another Ribonucleic acid species existed, messenger Ribonucleic acid.

In the early 1970s Pardee identified that the cell cycle has a point in the "G1" Phase where the cell, as it were, "commits" to moving to the "South" Phase.

Pardee published on this so-called "Restriction Point", sometimes called the "Pardee Point", in the Proceedings of the National Academy of Sciences in 1974 (A restriction point for control of normal animal cell proliferation, Proc National Academy Sciences United States of America 1974.

71:1286-1290).

Achievements

• Arthur Beck Pardee has been listed as a noteworthy biochemist, educator by Marquis Who's Who.

Membership

Member research advisory council American Cancer Society, 1967—1971. Trustee Cold Spring Harbor Laboratory Quantitative Biology, 1963—1969. Fellow: American Association for the Advancement of Science.

Member: National Academy of Sciences (editorial board proceedings 1971-1973, committee on science public policy 1973-1976), Chemical Industry Institute Toxicology (Founders award, Boehringer-Mannheim award 1998), Ludwig Institute Cancer Research (science committee since 1988), Japanese Bio-chemical Society, American Philosophical Society, American Society Microbiologists, American Association Cancer Research (president 1985-1986), American Society Biological Chemists (treasurer 1964-1970, president 1980-1981), American Chemical Society (Paul Lewis award 1960).

Interests

• Music, tennis, travel, art

Connections

Married Ruth Sager (deceased). Children by previous marriage: Michael, Richard, Thomas.

Father:

Charles A. Pardee

Mother:

Elizabeth B. (Beck) Pardee

Spouse:

Ann Goodman

Spouse:

Ruth Sager

child:

Thomas Pardee

child:

Michael Pardee

child:

Richard Pardee