He studied at the Sir J. J. School of Art in Mumbai between 1947 and 1950.
In 1950 he traveled to London, where he met Le Corbusier, and, for the next four years, Doshi worked in the famed architect’s studio in Paris. He returned to India to oversee the construction of some of Le Corbusier’s projects, including the Mill Owners’ Association Building (1954) and the Villa Sarabhai in Ahmedabad (1955). He eventually settled in that city, where he designed his own residence (1963), named Kamala House after his wife; his studio, Sangath (1980); and some of his most important projects.
In 1955 he married Kamala Savailal Parikh.