He may have studied with his uncle Giacinto Bondioli.
He traveled throughout his life, and occupied posts in Brussels, over thirty years in Neuburg an der Donau and Düsseldorf, and Venice in 1615, joining Monteverdi"s group at Saint Mark"s Cathedral, Padua, Parma, Ferrara, Milan, Bergamo, and Brescia in Italy. He died in Venice. Although he wrote both instrumental and vocal music, he is better known for his innovative instrumental compositions. He contributed to the early development of the string idiom by expanding the performance range of the solo and accompanied violin and incorporating slur, double and even triple stopping, and the first explicitly notated tremolo effects into his music
He was also among the first composers, after Marco Uccellini, to call for scordatura tunings.
He made contributions to most of the contemporary genres and investigated unusual compositional procedures, like constructing an entire sonata without a cadence (as in his Sonata senza cadenza). At least some, and perhaps a great deal, of his output is lost, but that which survives exhibits his inventiveness, lyrical skill, harmonic boldness, and growing tendency toward common practice tonality.
In addition to his violin works, he wrote music for the cornet, bassoon, and trombone.