Wetherell was born in Oxford, the third son of Reverend Nathan Wetherell, of Durham, Master of the University College and Vice-Chancellor of the University of Oxford. His mother was Richarda Croke (1743?-1812), sister of Sir Alexander Croke, of Studley Priory, Oxfordshire.
He was elected Member of Parliament for Hastings in 1826 but had to stand down when appointed Attorney-General. He represented Plympton Erle from December 1826 to 1830 and Boroughbridge from 1830 to 1832. He was Solicitor-General between 1824 and 1826 and Attorney General between 20 September 1826 and 27 April 1827 and again between 19 February 1828 and 29 June 1829.
In May 1829, Wetherell made a violent speech in opposition to Catholic Emancipation, and was dismissed by the Duke of Wellington.
He was Recorder of Bristol during the riots of 1831. From 1835 up to his death in 1846 he was Chancellor of Durham.
They had a son, Charles, who died in infancy.
Royal Society; 5th United Kingdom Parliament. 7th United Kingdom Parliament. 8th United Kingdom Parliament.
9th United Kingdom Parliament.
10th United Kingdom Parliament]
Wetherell was Member of Parliament for a considerable period, representing Rye from 1812 to 1813, Shaftesbury from 1813 to 1818, Oxford from 1820 to 1826.
