In early youth he went to Livorno with his learned father, Raphael Calvo, and on October 23, 1724, he graduated as a doctor in Padua.
Calvo practiced medicine with considerable success at Leghorn, but inclined to the Kabbala toward the end of his life. Several of Calvo"s poems are included in Bachelor of Arts Piperno"s collection Ḳol "Ugab, Leghorn, 1846. When Calvo died Joseph ben David wrote an elegy, which is published in his Yeḳara de-Shakbe, 1774.