He was a professor in the Academy of Fine Arts of Naples. Along with Camillo Guerra, Gennaro Maldarelli, and Giuseppe Cammarano, in 1841 he helped frescoe ceilings in the rooms of the Royal Palace of Naples. Marsigli completed the sala d’Amore, now the reading hall in the National library.
In the four ovals, he depicted stories of the Hours and Cupid: Tersicore che invita le Ore alla danza, La danza delle Ore, Prigionia di Cupido, and Fuga di Cupido. The same coterie of painters decorated the apse of the Cathedral of Caserta.