Frank P. DiPerna earned a Bachelor of Science in Mechanical Engineering at the Virginia Polytechnic Institute in Blacksburg (now Virginia Polytechnic Institute and State University) (1970). He specialized in photography at Goddard College in Plainfield, Vermont, where he completed a master's degree in 1971. He also attended a Center of the Eye Workshop in Aspen, Colorado, studying under Gary Winogrand (1971), and a Visual Studies Workshop in Rochester, where his instructors were Ralph Gibson, Nathan Lyons and Alice Wells (1971-1972).
Since 1974 Frank P. DiPerna has been teaching at the Corcoran School of Art in Washington, D.C., first as an instructor and, since 1978, as an assistant professor and chairman of the Photography Department. Previously he taught at the Northern Virginia Community College in Alexandria (1973-1978). From 1969 to 1971 he was a marine engineer/naval architect for the U.S. Coast Guard in Washington, D.C.
Until 1978 the artist worked mainly in 35mm black-and-white and in 8 x 10 palladium prints. At present he is more interested in using the Polaroid SX-70 as well as producing Type C color prints