Background
Triebel, Frédéric was born on November 20, 1954 in Douala, Cameroon. Son of Marcel and Odette Triebel.
immunologist officer Doctor of Medicine
Triebel, Frédéric was born on November 20, 1954 in Douala, Cameroon. Son of Marcel and Odette Triebel.
He completed his Doctor of Medicine degree at Poitiers University in 1981 and then a four-year clinical hematology fellowship in Paris hospitals. In parallel, Triebel gained a Doctor of Philosophy in Immunology at the University of Paris VI in 1985. His Doctor of Philosophy thesis was in the field of immunogenetics, focused on the mechanisms that activate human antigen-specific T-cells.
Triebel worked through the 1990s in a collaboration between Institut Gustave Roussy and Merck Serono to establish LAG-3’s mechanism of action in T cells and dendritic cells. In 2001 he founded Société Anonyme, a biotech company, to develop the therapeutic potential of LAG3. In 2014 this company was acquired by Prima BioMed, where Triebel remains Chief Scientific and Medical Officer.
In 1983, Frédéric Triebel received the Gold Medal of the Paris Medicine University.
From 1986 until the late 1990s, Triebel headed the cellular immunology group in the Department of Clinical Biology of the Institut Gustave Roussy. In 1990 he gained a Chair in Molecular Immunogenetics and Biotherapy at the University of Paris XI. Between 1991 and 1996 was director of an Institut national de la santé et de la recherche médicale unit (U333).
He founded Société Anonyme in 2001 in order to develop the clinical potential of LAG3 and stayed with this company through to its acquisition by Prima BioMed in 2014. Triebel remains Chief Scientific and Medical Officer of Prima BioMed.
Triebel reported the first cloning of the LAG3 gene in 1990, and two years later his team were able to show that the LAG-3 protein was a ligand for Major histocompatibility complex Class II molecules like CD4.
In 1997 the Triebel lab identified the LAG-3 amino-acid residues involved in LAG-3/Major histocompatibility complex class II interaction. In 1998 Triebel et al. performed the first characterization of the human CD4/LAG-3 gene locus, in the process identifying the LAG-3 promoter regulatory elements. Also in 1998 the Triebel team were the first to characterizing the negative regulatory role of LAG-3 on CD3/TCR signaling.
His team was the first to show that, as a soluble molecule, LAG-3 activates antigen-presenting cells through Major histocompatibility complex class II signalling, resulting in antigen-specific T-cell responses.
Soluble LAG3, in a dimeric recombinant form called LAG-3Ig is now Prima BioMed"s lead compound. Frédéric Triebel founded in 2001 with John Hawken, a bioentrepreneur, to acquire the intellectual property which Triebel had created with Institut national de la santé et de la recherche médicale and the Institut Gustave Roussy related to LAG3 and then move LAG3-based products into the clinic.
Serono granted an exclusive worldwide license. The company raised €2.5m in venture capital in late 2003 and another €2.5m in January 2005.
Between 2001 and 2014 scientists did further basic and applied research on LAG3 and also completed a number of clinical studies, most notable in metastatic renal cell carcinoma in 2009 and metastatic breast cancer in 2010. was sold to Prima BioMed in 2014 for United States$25m.
1983: Gold Medal, Paris Residency program
2000: Prix Lucien Tartois de la Fondation pour la Recherche Médicale.
Vice president Ligue Contre le Cancer, Comité des Yvelines, Versailles, France, 1999—2003. Member of Société Française d'Immunologie (associate).
Married Nathalie David, September 22, 1984. Children: Jérome, Eléonore, Foucauld.