George Hoyningen-Huené was born on September 4, 1900 in Saint Petersburg City, Russian Federation. George Hoyningen-Huené was the only son of Baron Barthold Theodor Hermann (Theodorevitch) von Hoyningen-Huene (1859-1942), a Baltic nobleman, military officer and lord of Navesti manor (near Võhma), and his wife, Emily Anne "Nan" Lothrop (1860-1927), a daughter of George Van Ness Lothrop, an American minister to Russia. (The couple was married in Detroit, Michigan, in 1888.) He had two sisters Helen (died 1976) became a fashion designer in France and the United States, using the name Helen de Huene and Elizabeth (1891-1973), also known as Betty, also became a fashion designer (using the name Mme. Yteb in the 1920s and 1930s) and married, first, Baron Wrangel, and, second, Lt. Col. Charles Norman Buzzard, a British Army officer.