Yakulov was born in Tiflis, Russian Empire (now Tbilisi, Georgia), on January 16, 1884. His father, lawyer Bogdan Galustovich Yakulyan, died soon after Georgy Yakulov's birth. In 1893 Yakulov's mother took her children with her and moved to Moscow. Georgy Yakulov had two older brothers A. B. Yakulov and Ya. B. Yakulov, both were lawyers.