In 1973 was nominated for the Golden Globe Award for Best Supporting Actress – Motion Picture for her role as Jackie Burdette in Kansas City Bomber. During the late 1960s, Helena Kallianiotes was the resident belly dancer at The Intersection, a Greek restaurant in North Hollywood, California. This engagement led to her first film appearance as an uncredited belly dancer in the 1968 film Head, directed by Bob Rafelson and starring The Monkees.
Other film roles include Mata Hari in Shanks (1974), Elaine Reavis in The Drowning Pool (1975), Anita in Stay Hungry (1976), and the Visionary Woman in The Passover Plot (1976).
Helena Kallianiotes is featured on the cover of Art Garfunkel"s LP Breakaway.