Some of Sanada's more famous movies are: Tasogare Seibei (The Twilight Samurai), Ring, Kaitō Ruby, and The Last Samurai. Sanada played Matsuda, the Japanese imperialist who befriends Ralph Fiennes' character in the 2005 film The White Countess directed by James Ivory. He also made an appearance in the Chinese film The Promise directed by Chen Kaige. Sanada has also been seen in Rush Hour 3 with Jackie Chan and Chris Tucker and starred in 2007's The City of Your Final Destination, another James Ivory film, where he plays the younger lover of Anthony Hopkins's character.
Sanada joined the cast of the ABC show Lost in 2010 during its sixth and final season. In March 2011 he was named to the Keanu Reeves–led cast of 47 Ronin, the first English-language adaptation of the Chushingura legend, Japan's most famous tale of samurai loyalty and revenge.
1994 Won Festival Prize Best Actor for: Bokura wa minna ikiteiru (1993), Nemuranai machi - Shinjuku same (1993) and Yamai wa kikara: Byôin e ikô 2 (1992).
1989 Won Festival Prize Best Actorfor: Kaitô Ruby (1988).
1994 Won Festival Prize Best Actor for: Bokura wa minna ikiteiru (1993), Nemuranai machi - Shinjuku same (1993) and Yamai wa kikara: Byôin e ikô 2 (1992).
1989 Won Festival Prize Best Actorfor: Kaitô Ruby (1988).
Nikkan Sports Film Awards,
Japan
2002 Won Nikkan Sports Film Award Best Actor for: Tasogare Seibei (2002).
1995 Won Nikkan Sports Film Award Best Actor
for: Sharaku (1995), East Meets West (1995) and Kinkyu yobidashi - Emâjenshî kôru (1995).
1988 Won Nikkan Sports Film Award Best Supporting Actor
for: Kaitô Ruby (1988).
2002 Won Nikkan Sports Film Award Best Actor for: Tasogare Seibei (2002).
1995 Won Nikkan Sports Film Award Best Actor
for: Sharaku (1995), East Meets West (1995) and Kinkyu yobidashi - Emâjenshî kôru (1995).
1988 Won Nikkan Sports Film Award Best Supporting Actor
for: Kaitô Ruby (1988).
Mainichi Film Concours,
Japan
2003 Won Mainichi Film Concours Best Actor
for: Tasogare Seibei (2002) and Sukedachi-ya Sukeroku (2001).
2003 Won Mainichi Film Concours Best Actor
for: Tasogare Seibei (2002) and Sukedachi-ya Sukeroku (2001).
Kinema Junpo Awards,
Japan
2003 Won Kinema Junpo Award Best Actor
for: Tasogare Seibei (2002) and Sukedachi-ya Sukeroku (2001).
1996 Won Kinema Junpo Award Best Actor
for: Sharaku (1995), East Meets West (1995) and Kinkyu yobidashi - Emâjenshî kôru (1995).
1994 Won Kinema Junpo Award Best Actor
for: Bokura wa minna ikiteiru (1993) and Nemuranai machi - Shinjuku same (1993).
1989 Won Kinema Junpo Award Best Actor
for: Kaitô Ruby (1988).jensh
2003 Won Kinema Junpo Award Best Actor
for: Tasogare Seibei (2002) and Sukedachi-ya Sukeroku (2001).
1996 Won Kinema Junpo Award Best Actor
for: Sharaku (1995), East Meets West (1995) and Kinkyu yobidashi - Emâjenshî kôru (1995).
1994 Won Kinema Junpo Award Best Actor
for: Bokura wa minna ikiteiru (1993) and Nemuranai machi - Shinjuku same (1993).
1989 Won Kinema Junpo Award Best Actor
for: Kaitô Ruby (1988).jensh
Hochi Film Awards,
Japan
1995 Won Hochi Film Award Best Actor
for: Sharaku (1995), East Meets West (1995) and Kinkyu yobidashi - Emâjenshî kôru (1995).
1988 Won Hochi Film Award Best Actor
for: Kaitô Ruby (1988).
1995 Won Hochi Film Award Best Actor
for: Sharaku (1995), East Meets West (1995) and Kinkyu yobidashi - Emâjenshî kôru (1995).
1988 Won Hochi Film Award Best Actor
for: Kaitô Ruby (1988).
Blue Ribbon Awards,
Japan
2006 Won Blue Ribbon Award Best Actor
for: Bôkoku no îjisu (2005).
1996 Won Blue Ribbon Award Best Actor
for: Sharaku (1995), East Meets West (1995) and Kinkyu yobidashi - Emâjenshî kôru (1995).
1994 Won Blue Ribbon Award Best Actor
for: Bokura wa minna ikiteiru (1993).
2006 Won Blue Ribbon Award Best Actor
for: Bôkoku no îjisu (2005).
1996 Won Blue Ribbon Award Best Actor
for: Sharaku (1995), East Meets West (1995) and Kinkyu yobidashi - Emâjenshî kôru (1995).
1994 Won Blue Ribbon Award Best Actor
for: Bokura wa minna ikiteiru (1993).
Awards of the Japanese Academy,
Japan
2006 Nominated Award of the Japanese Academy Best Actor
for: Bôkoku no îjisu (2005).
2003 Won Award of the Japanese Academy Best Actor
for: Tasogare Seibei (2002).
1994 Nominated Award of the Japanese Academy Best Actor
for: Nemuranai machi - Shinjuku same (1993) and Bokura wa minna ikiteiru (1993).
1991 Nominated Award of the Japanese Academy Best Actor
for: Tugumi (1990), Byôin e ikô (1990) and Rimeinzu: Utsukushiki yuusha-tachi (1990).
1985 Nominated Award of the Japanese Academy Best Actor
for: Mâjan hourouki (1984), Irodori-gawa (1984) and Satomi hakken-den (1983).
1982 Won Newcomer of the Year for: Makai tenshô (1981), Hoero tekken (1982) and Bôkensha kamikaze (1981).
2006 Nominated Award of the Japanese Academy Best Actor
for: Bôkoku no îjisu (2005).
2003 Won Award of the Japanese Academy Best Actor
for: Tasogare Seibei (2002).
1994 Nominated Award of the Japanese Academy Best Actor
for: Nemuranai machi - Shinjuku same (1993) and Bokura wa minna ikiteiru (1993).
1991 Nominated Award of the Japanese Academy Best Actor
for: Tugumi (1990), Byôin e ikô (1990) and Rimeinzu: Utsukushiki yuusha-tachi (1990).
1985 Nominated Award of the Japanese Academy Best Actor
for: Mâjan hourouki (1984), Irodori-gawa (1984) and Satomi hakken-den (1983).
1982 Won Newcomer of the Year for: Makai tenshô (1981), Hoero tekken (1982) and Bôkensha kamikaze (1981).