Isaac Mizrahi was born in Brooklyn, New York, October 14, 1961, the youngest child and only son of Zeke and Sarah Mizrahi. He would often accompany his mother on shopping trips to Saks Fifth Avenue and Bergdorf Goodman.
Zeke Mizrahi worked in the garment industry, first as a pattern cutter on Wooster Street and later as a childrenswear manufacturer. Isaac's mother was instrumental in exposing him to fashion at an early age. A devoted fashion lover, Sarah Mizrahi exposed young Isaac to the genius of designers Balenciagas, Chanel, and Norman Norell. He would often accompany his mother on shopping trips to Saks Fifth Avenue and Bergdorf Goodman. She would also take Isaac to the ballet and to movies. When Isaac was eight, his family moved to the middle-class Midwood section of Brooklyn. He contracted spinal meningitis during this time and his confinement was spent eating junk food and viewing television, especially old movies.