(753p brown hardback with gilt lettering to cover and spin...)
753p brown hardback with gilt lettering to cover and spine, little use, pages clean with frontispiece and facsmilie signature, diagrams and biographical memoirs, very good, edited by Andre Lwoff and Agnes Ullmann, this is the (first) 1978 edition.
http://www.amazon.com/gp/product/012460482X/?tag=2022091-20
(The French biochemist explains his revolutionary theory o...)
The French biochemist explains his revolutionary theory of genetics and speculates on its ethical, political, and philosophical implications
http://www.amazon.com/gp/product/0394718259/?tag=2022091-20
Jacques Lucien Monod was born in Paris, France, on February 10, 1910 to an American mother from Milwaukee, Charlotte (Sharlie) MacGregor Todd, and a French Huguenot father, Lucien Monod who was a painter and inspired him artistically and intellectually. He spent most of his youth in Cannes, in the south of France.
He developed an interest in biology from his father, who was an avid reader of Darwin.
He attended the lycée at Cannes until he was 18. In 1928 he went to Paris to pursue a college education at the Faculte des Sciences of the University of Paris. He received a Bachelor's degree in natural science in 1931.
In France he received his D. Sc. in 1941 from the University of Paris
He obtained a fellowship to work with Edouard Chatton at the University of Strasbourg. He was engaged in research on the evolution of life from 1932 to 1934, when he was appointed assistant professor of zoology at the Faculte des Sciences. In 1936 he obtained a Rockefeller fellowship to study genetics at the California Institute of Technology. He was appointed laboratory chief at the Pasteur Institute in 1945. Eight years later he became the head of the institute's department of cellular biochemistry. He was appointed full professor at the Faculte des Sciences in 1959 and director general of the Institute Pasteur in 1971. Jacques Monod died of illness in 1976.
Monod shared the Nobel Prize in Physiology/Medicine in 1965 with Andre Lwoff and Francois Jacob for his role in elucidating the nature of messenger RNA (ribonucleic acid) and the operon structure of the gene. At the time he did his work the field of genetics was in a state of turmoil. It had been discovered that DNA (deoxyribonucleic acid) was the primary chemical constituent of the hereditary material - "the genetic code. "
What was not known, however, was the process by which DNA contained in the nucleus could confer the genetic information it carried to cellular regions outside the nucleus (the cytoplasm). How did the DNA "communicate" with enzymes (biological catalysts) and other structures involved in protein synthesis, all of which were located in the cytoplasm? It was this mystery that Monod set about solving. Biologists had known for some time that RNA differed from DNA in that it is present both inside the cell nucleus and in the cytoplasm, whereas DNA is only present in the nucleus. Mahlon Hoagland and Paul Zimmerick of Harvard University had shown that the carrier of amino acids in the cytoplasm during certain chemical reactions was a type of RNA they dubbed "transfer" RNA. Scientists at the Oak Ridge National Laboratories discovered that, after bacteriophage (a virus composed of a core of DNA surrounded by a layer of protein which infects only bacteria) infection, a kind of RNA was formed that was similar to the DNA originally in the bacteriophage. They named this type "DNA-like RNA. " While this substance was subsequently isolated in other laboratories, its role in the formation, or synthesis, of protein remained a mystery.
In the mid-1940 Monod found that the synthesis of an enzyme known as-galactosidase could be prevented by infection by bacteriophage without affecting the actual activity of the enzyme. This was a curious discovery, and it prompted him to look for the relationship between-galactosidase and the gene which coded for its production. After several years of research he found that there was a relationship between the activity of the enzyme and protein synthesis.
Monod carried out more experiments in this area in 1958 with Francois Jacob and Arthur Pardee. The results of these experiments and others led Monod and Jacob to propose the ideas of messenger RNA and the operon. Their idea was that, through a process resembling the one in which DNA reproduces itself within the nucleus, a kind of RNA is formed from the DNA template that contains an exact copy of the genetic information contained in the DNA. This RNA was the "DNA-like RNA" observed earlier; Monod and Jacob named it messenger RNA, due to the communicative role it played between structures located on either side of the nuclear membrane. Upon entering the cytoplasm messenger RNA associates itself with ribosomes, which are small granules composed of ribosomal RNA, essential to protein synthesis. The messenger-ribosomal RNA complexes then combine with transfer RNA to initiate protein synthesis. The operon is composed of a series of structural genes regulated by a single shared gene known as their operator. If the operator is "open, " the genes can generate messenger RNA; when it is "closed, " there is no messenger RNA. The idea of the operon helped to explain certain important aspects of enzyme synthesis as well as aspects of phage phenomena. The idea of messenger RNA is extremely important because it explains the previously missing link in how DNA initiates protein synthesis, which is a crucial factor in the ability of cells to function.
He discovered messenger RNA, a crucial factor in the functioning of the cell. Monod (along with François Jacob) became famous for his work on the E. coli lac operon, which encodes proteins necessary for the transport and breakdown of the sugar lactose (lac). He is widely regarded as one of the founders of molecular biology.
He won the Nobel Prize in Physiology or Medicine in 1965. Jacques Monod received the Louis Rapkine Medal in London in 1958. In 1963 he was awarded the Legion d'Honneur, one of the highest distinctions possible for a Frenchman.
(753p brown hardback with gilt lettering to cover and spin...)
(The French biochemist explains his revolutionary theory o...)
Monod stated we are merely chemical extras in a majestic but impersonal cosmic drama-
an irrelevant, unintended sideshow. His views were in direct opposition to the religious certainties of his ancestor Henri's well-known brothers Frédéric Monod and Adolphe Monod.
Quotations:
"The first scientific postulate is the objectivity of nature: nature does not have any intention or goal. "
"The universe is not pregnant with life nor the biosphere with man. .. Man at last knows that he is alone in the unfeeling immensity of the universe, out of which he emerged only by chance. His destiny is nowhere spelled out, nor is his duty. The kingdom above or the darkness below; it is for him to choose"
In 1960 he was designated an honorary member of the American Academy of Arts and Sciences.
He possessed a great love for music, almost accepting an invitation offered him by an American orchestra to be their conductor. He was also extremely interested in literature and spoke fluent English.
He had been married to Odette Bruhl, who died in 1972. They left twin sons, Olivier and Philippe.
