All the known facts of his life and activity are from the Musikalischen Lexikon by Johann Gottfried Walther (Johann Sebastian Bach"s cousin), a dictionary which first appeared in 1732. Between 1670 and 1674 he is said to have remained a violinist in the orchestra of Cosimo III of the Medicis in Florence. From 1674 he was concertmaster at the court of Dresden.
After the death of his patron in 1680 he became the Italian secretary at the elector"s court in Mainz and was ordained a canon.
He died in Mainz. Alongside Biber and Westhoff, Walther is one of the most significant German violinists of the 17th century.