Doctor of Medicine, Vrije University Amsterdam, 1977. Doctor of Philosophy, Maastricht University, Netherlands, 1986.
Professor general practice Maastricht University, since 1988. Dean Maastricht University Medical School, 1990—1991. Science director Netherlands School Primary Care Research, 1994—2002.
Editor-in-chief Journal Clinical Epidemiology, since 1998. President Health Council Netherlands, The Hague, 2001—2010. Chairman Science Council Government Policy, since 2010.
Chairman medical section Royal Netherlands Academy of Sciences, Amsterdam.
Married Maria Willemina Wolleswinkel. Children: Bartholomeus Johannes, Pieter Rens.