Originally from Mechelen in Belgium, he moved across the North Sea to work in England in the second half of the 17th century, gaining employed with the sculptor Arnold Quellin as a foreman. After Quellin"s death in 1686 Nost married his widow, and established his own sculptural works business in the Haymarket district of London. He was prolific and received many commissions, including employment at Hampton Court Palace, Melbourne Hall, Castle Howard, Buckingham Palace and Chatsworth.
Many of his statues were in cast lead.
Van Nost died at his home at Hyde Park in London on 26 April 1729.