Karam studied at Cairo University in Cairo, Egypt. In 1973 he received a degree of the Bachelor of Science in Aerospace Engineering. In four years Karam became a Doctor of Philosophy in Aerospace Engineering.
Karam worked as an Airframe maintenance engineer in Egyptian Airforce in Cairo, Al Qahirah, Egypt from 1974 to 1976. He was a Research engineer in National Research Center from 1976 to 1981. He worked as a Computer programmer consultant, since 1980.
Karam married to Mirande Badih Habib on July 25, 1957. They have to children: George Karam, Mariam Karam.