Kshetresa Chandra Chattopadhyaya studied in a number of schools and passed the matriculation examination of the Calcutta University in 1913 from Hindu School of Calcutta. He then attended the Presidency College, Calcutta for Intermediate examination and passed in 1915. He then migrated to the United Province of Agra and Oudh and passed the Bachelor of Arts examination of Allahabad University (1917) and Master of Arts in Sanskrit from Queen's College, Benares (1919).
He also passed the Master of Arts Examination in Veda from Calcutta University in 1921 and Vedant in 1922.
He in his college days became an intimate friend of Subhas Chandra Bose who later became a prominent figure in Indian politics and the Indian independence movement. Chattopadhyaya was a student of Doctor Ganganath Jha.
He came from an illustrious family of Kulina Brahmans of Deshmukho in District Hooghly. The Indian writer Bankim Chandra Chattopadhyay belonged to the same family and Kshetresa Chandra Chattopadhyaya inherited the spirit of Indian renaissance from him. Kshetresa Chandra Chattopadhyaya joined University of Allahabad as a lecturer in the department of Sanskrit in 1924.
In the year 1950 he was promoted to reader and from 1956 for about a couple of years he acted as professor of Sanskrit.
Later he became Director, Research Institute at Sampurnanand Sanskrit University, Benares. As the director, he was in a position to guide research exclusively.
Chattopadhyaya was the editor of book series Sarasvati Bhavana Granthamala and famous Sanskrit Journal, Sarasvati Susama. He was also appointed as a special scholar for comparative study of Veda and Avesta by the Ministry of, Government of India at Kendriya Sanskrit Vidyapeeth, Tirupati.
The Calcutta University appointed him Stephan’s Nirmalendu Ghosh Lecturer on Comparative Religion in 1960 (In that period he was on leave from Sampurnanand Sanskrit University).
He has produced many scholars, among them are B P T Vagish Shastri Vidya Niwas Mishra Govind Chandra Pande Govardhan Rai Kamlesh Dutt Tripathi Eshakenopanishad (First Edition 1916), Reprinted in University Bi-Centenary Series, (Editor BN Mishra), Volume(s) VIII, Sampurnanand Sanskrit University, 1992. Vedavittaprakasika, 1966. Studies in Vedic and Indo-Iranian Religion and Literature, (EdVidya Niwas Mishra), 1976.