After a long period of studying at the Academy of Dramatic Arts, she made her breakthrough role in Duccio Tessari"s Una grande storia d"amore (1986), which was followed by roles in Daniele Luchetti"s two projects lieutenant"s Happening Tomorrow (1988) and The Week of the Sphinx (1990). After The Station, she became a premier star featuring in Italian box office hits like Carlo Verdone"s Damned the day I met you (1992). She teamed up again with director Daniele Luchetti for The Storm Is Coming (1992) and worked with Mario Monicelli in Looking for Paradise (1995) and Pozzessere (An Eyewitness Account).
Her performance in I giorni dell"abbandono by Roberto Faenza earned her the Golden Graal for best performance by an actress in a drama.
Il caimano by Nanni Moretti, shown at the 2006 Cannes film festival, gave her the Ciak d"oro 2006 award as best lead actress.