De Gli Antoni has a master"s degree in music composition from the Mannes College of Music in New York City. Since Soul Coughing, he has devoted his energy toward film scoring. Notable are the films Cherish, Marie and Bruce, the Home Box Office documentary Roman Polanski: Wanted and Desired. and Into the Abyss by acclaimed director Werner Herzog.
In 2013, Mark composed the score for the documentary feature, Plimpton! Starring George Plimpton as Himself, which played theatrically before airing on American Masters.
Mark has toured with Low, John Scofield and David Byrne on the Songs of David Byrne and Brian Eno Tour.
In the early 1990s, degli Antoni was a member of the composers" collective Rough Assemblage.