Background
Al-Sayah, Mohammad Hussein Son of Hussein and Souraya Al-Sayah.
(Allosterism has long been used by Nature to control the a...)
Allosterism has long been used by Nature to control the activity of its receptors and enzymes. The binding of a cofactor to an allosteric site induces conformational changes in the receptor rendering its binding (active) site unsuitable to accommodate the substrate. The activity of the receptor is regenerated by removing the allosteric cofactor or by regulating its binding properties. This book describes the utilization of allosterim to control the binding activity of man-made synthetic receptors. The strategies and the elements of allosteric control that are vital in the design of a receptor with hydrogen-bonding active site are presented. The book also introduces different approaches and cofactors for activity control. Finally, detailed experimental procedures for synthesis and binding investigations of a series of artificial receptors are demonstrated including NMR titrations.
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Al-Sayah, Mohammad Hussein Son of Hussein and Souraya Al-Sayah.
Bachelor of Science, American University Beirut, Lebanon. Master of Science, American University Beirut, Lebanon, 1996. Doctor of Philosophy, University Alberta, Edmonton, Canada, 2002.
Research associate Scripps Research Institute, La Jolla, California, 2002—2004. Professor American University Sharjah, United Arab Emirates, since 2004.
(Allosterism has long been used by Nature to control the a...)
Member of International Union of Pure and Applied Chemistry, American Chemical Society.
Married Amal Al-Kadri. 1 child Mira.