Background
Sakamoto, Naoto was born on February 3, 1939 in Karatsu, Japan. Son of Hitoshi and Asako (Matsuo) Sakamoto.
(This book is concerned with a quantitative analysis of dy...)
This book is concerned with a quantitative analysis of dynamic behavior of various enzymatic reaction systems by computer simulation. The authors and coworkers have been engaged in cooperative research since 1975, seeking to clarify the catalytic and regulatory characteristics of enzymatic reactions in vivo and control mechanisms suitable for enzyme technology. Rather than "enzyme kinetics" generally known in enzymol· ogy, this research has employed an approach called "enzyme dynamics" which concentrates on the exact schematic representation of an actual reac tion mechanism, derivation of rate equation on the basis of the scheme, and computer simulation of its dynamic behavior (numerical solution of the rate equation and explanation of kinetic and regulatory properties of the enzymatic reaction). A rate equation representing the behavior of enzymatic reactions is gen erally expressed by a set of nonlinear differential equations. The analytic solution of rate equations is therefore impossible in general, making it necessary to introduce some approximations in order to analyze the exper· imental data in enzyme kinetics. For example, under an assumption of excess substrate against enzyme in a closed system, we commonly use the linear approximation for the early period of reaction, the quasi-steady state approximation based on putative maintenance of steady state in en zyme species, and the rapid-equilibrium approximation assuming instantane ous equilibration in complex formation and between complexes. The kinetic characteristics obtained by these approximations do not always reflect the dynamic behavior of actual enzymatic reactions.
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Sakamoto, Naoto was born on February 3, 1939 in Karatsu, Japan. Son of Hitoshi and Asako (Matsuo) Sakamoto.
Bachelor of Engineering, University Tokyo, 1961. Master of Engineering, University Tokyo, 1963. Doctor of Philosophy, University Southern California, Los Angeles, 1971.
Engineer, Chiyoda Chemical Engineering and Construction Company, Yokohama, Japan, 1963-1965; research assistant, University of Southern California, Los Angeles, 1965-1966; research associate, University of Michigan, Ann Arbor, 1971-1973; research associate, Kyushu U., Fukuoka, Japan, 1974-1975; research fellow, Institute Physical and Chemical Research, Wako, Japan, 1975-1978; associate professor, U. Tsukuba, Japan, 1978-1988; professor, U. Tsukuba, Japan, since 1988.
(This book is concerned with a quantitative analysis of dy...)
Member Japan Bio-chemical Society, Society Instrument and Control Engineers, Society for Mathematics Biology, International Association Mathematics and Computers in Simulation.
Married Hiroko Satou, January 7, 1963.