Career
He was Dean of Hereford, Master of University College, Oxford and Vice-Chancellor of Oxford University. Nathan Wetherell was originally from Durham. As Vice-Chancellor of Oxford, he set up the Oxford Paving Commission in 1771 to supervise paving, cleaning and lighting in the city of Oxford.
Wetherell was married to Richarda Croke (1743?–1812), sister of Sir Alexander Croke, of Studley Priory, Oxfordshire.