Born in Brittany, he was the son of Raoul-Guillaume Coulon, sieur de Villiers and Louise de Lafosse (m1677, Beaumont-sur-Oise). In 1705, he married Angelique Jarret de Verchères (daughter of François Jarret de Verchères and Marie Perrot and sister Madeleine) in Quebec.
He was an officer in New France. Nicolas Antoine arrived in Quebec in 1703. At some time before 1718, Nicolas may have married Mme de Louisiana Chesaigne.
In 1715, he became lieutenant in the French army.
From 1725 to 1730, Nicolas was officer in command of Fort Saint Joseph. From this fort, he conducted in August of 1730, a regiment of Canadiens and Amerindians against Fort Mesquakie of the Fox, constructed 60 ligues south of Lake Michigan, and joined the forces of Canadians at Fort Chartres and Fort Miami to prepare for the extermination of this tribe.
In January 1731, the survivors of this campaign went to Nicolas Antoine at Fort Saint-Joseph, and later in the year, they accompanied them to Montreal, where Governor Marquis de Beauharnois forgave them. (The writings of de Montigny at Michilimackinac).
From 1731 until his death - he was killed by a Sauk in 1733 - he commanded and rebuilt the fort at Louisiana Baye in the Wisconsin.
