Career
Yoon has starred in films such as Oldboy, All for Love, A Good Day to Have an Affair, and Secret Love. She also appeared in a variety of television series — historical drama The Return of Iljimae, action comedy The Fugitive: Plan B, and cable romantic comedy Twelve Men in a Year. Yoon was a contributing writer at Movieweek magazine, writing 11 articles over the period of 2010 to 2011 under the column 윤진서의 롤링 페이퍼 ("Yoon Jin-seo"s Rolling Paper").
In November 2012, Lee signed on to be exclusively managed by FNC Entertainment.
Yoon adheres to a vegetarian diet for ethics and health reasons. She dated LG Twins baseball player Lee Taek-Keun from 2009 to 2010.
In June 2012, Yoon was hospitalized following an alleged suicide attempt, which her agency denied, saying it had been an accidental overdose of cold medicine.