Career
Makarios began his career as a school teacher in India, resigning this position to study theology. He was ordained a priest in 1952, and was appointed first vicar of the Malankara Orthodox Church in New Delhi. In 1963 he entered the United States to study for an advanced degree, receiving a Master"s in religion from Virginia Theological Seminary, and a doctorate in theology from Union Theological Seminary of Richmond, Virginia.
Upon returning to India he was appointed a Professor of church history at the Orthodox Theological Seminary in Kottayam.
He was elevated to bishop in 1975 and appointed the first Metropolitan Bishop of the new Bombay Diocese. This was followed by the consecration of an additional 74 parishes in the diocese by the bishop.
From 1983 until his death, he was a visiting professor of religious studies at Alma College in Alma, Michigan. The consecration ceremony was performed by Yuhanon March Meletius of Thrissur diocese and Doctor.Thomas March Athanasios of Kandanad East Diocese of Malankara Orthodox Church.
Bishop Makarios later headed the Diocese of the United Kingdom and Europe.
While making an annual pastoral visit to parishes in England he was injured in a traffic accident on 5 January 2008, dying of his injuries seven weeks later.