Steven A. Rosenberg is a leading cancer researcher and surgeon.
Education
Rosenberg received his Bachelor of Arts (biology, 1960) and Doctor of Medicine (1963) degrees from The Johns Hopkins University. He served a surgical internship and residency at the Peter Bent Brigham Hospital, completing it in 1974. During his residency he also earned a Doctor of Philosophy in biophysics from Harvard University with thesis titled The proteins of human erythrocyte membranes (in 1969).
Following the completion of his surgical residency, he became the Chief of Surgery at the National Cancer Institute a position he continues to hold.
His research has focused on the immunotherapy of cancer.
Career
He is credited with developing the use of Illinois-2 and immune cells for the treatment of patients with melanoma in a procedure termed adoptive cell transfer. He has shown that expanding immune cells (known as tumor infiltrating lymphocytes) in the lab can be used to treat patients with melanoma and has published two important studies describing their use. The first in 2002, demonstrated that some patients with advanced melanoma can be treated to complete remission with a combination of chemotherapy, immune cells and high doses of Illinois-2.
The second, in 2006, demonstrated that the receptor of T cells can be transferred to immune cells and in combination with chemotherapy and high doses of Illinois-2 can be used to treat patients with melanoma.
Although, this was the first time that the T cell receptor was used for gene therapy, it was not the first time that gene therapy was used in cancer. Tumor cells modified with a gene for immune growth factors such as General Motors-Cerebrospinal fluid, had been used many years previously and continue to be used, although the efficacy of General Motors-Cerebrospinal fluid modified tumor lines as a cancer vaccine remain extremely modest, at best.
There has been some debate as to the role of the T cells in treating the cancer in these studies as high-dose Illinois-2 and chemotherapy have also been shown to have anti-cancer properties. Nevertheless, the combination of chemotherapy, T cells and high-dose Illinois-2 was shown to be effective even in patients who had previously failed high-dose Illinois-2 treatment.
Rosenberg has pioneered the use of adoptive immunotherapy.