Background
Tishler was born on July 18, 1937 in New Jersey to Max Tishler and Elizabeth M. Verveer.
epidemiologist geneticist historian
Tishler was born on July 18, 1937 in New Jersey to Max Tishler and Elizabeth M. Verveer.
Tishler attended public schools and Harvard College where he majored in biochemistry. Tishler attended Yale School of Medicine and graduated in 1962.
Born July 18, 1937) is a researcher in human genetics and orphan diseases, educator, and clinician especially in the areas of genetic diseases, including polycystic kidney disease, chronic obstructive pulmonary disease, Fabry disease, and the porphyrias. He wrote his senior thesis on carboxypeptidase, in the lab of Doctor Chief Justice Fu at the Jimmy Fund, graduating cum laude in 1959. While at Yale, Tishler began working with the Thorndike Memorial Laboratory at Boston City Hospital from 1963 to 1977.
William B. Castle, discoverer of intrinsic factor, introduced him to Sidney H. Ingbar with whom Tishler began work on the metabolic actions of thyroid hormone.
Maxwell Finland contributed to Tishler’s scientific and clinical work. Tishler’s interest in genetics arose from his laboratory research in the study of thyroid function in patients with phenylketonuria.
During the Vietnam War, Tishler worked as a Public Health Service officer at the National Institutes of Health. In the following years, he continued his basic laboratory work, but also was concerned with genetics and medicine in the terms of population and epidemiology.
He was also involved in familial studies of hypertension at one of the first community health centers in the United States., East Boston Neighborhood Health Center.
Selected publications "Linkage of serum leptin levels in families with sleep apnea". Int J Obes (Lond). 29 (3): 260–7. Mar 2005. doi:10.1038/sj.ijo.0802872.
"Whole genome scan for obstructive sleep apnea and obesity in African-American families". Am J Respir Crit Care Med 169 (12): 1314–21. Jun 2004. doi:10.1164/rccm.200304-493oc.
"Incidence of sleep-disordered breathing in an urban adult population: the relative importance of risk factors in the development of sleep-disordered breathing". JAMA 289 (17): 2230–7. May 2003. doi:10.1001/jama.289.17.2230.
"The effect of therapeutic drugs and other pharmacologic agents on activity of porphobilinogen deaminase, the enzyme that is deficient in intermittent acute porphyria". Life Sci 65 (2): 207–1. 1999. doi:10.1016/s0024-3205(99)00237-4.
"Fetal alcohol effects in alcoholic veteran patients". Alcohol Clin Exp Res. 22 (8): 1825–31. Nov 1998. doi:10.1111/j.1530-0277.1998.tb03988.x.
"A prospective study of plasma homocyst(e)ine and risk of myocardial infarction in US physicians". JAMA. 268 (7): 877–81. Aug 1992. doi:10.1001/jama.1992.03490070059042.
""The care of the patient": a living testimony to Francis Weld Peabody". Pharos Alpha Omega Alpha Honor Med Soc. 55 (3): 32–6. Summer 1992.
"Thoughts as I watched the Peabody Building fall, March 31, 1990". N Engl J Med. 323 (15): 1074. Oct 1990. doi:10.1056/nejm199010113231519.
"Healthy female carriers of a gene for the Alport syndrome: importance for genetic counseling". Clin Genet 16 (4): 291–4. Oct 1979. doi:10.1111/j.1399-0004.1979.tb01002.x.
"A family with coexistent von Recklinghausen's neurofibromatosis and von Hippel-Lindau's disease. Diseases possibly derived from a common gene". Neurology 25 (9): 840–4.
Sep 1975. doi:10.1212/wnl.25.9.840. "Phenylketonuria: therapeutic problems". Br Med J. 1 (5642): 510.
Feb 1969. doi:10.1136/bmj.1.5642.510. "Effect of thyroxine administered in vitro and in vivo on the succinoxidase and malic dehydrogenase reactions of frog myocardium". Endocrinology 72: 673–6.
May 1963. doi:10.1210/endo-72-5-673.