She acted in more than 170 films and produced about 25 films in Telugu and Tamil languages during the 1930s to the 1960s. She started acting in dramas at the age of 13. She performed many characters such as Sati Savitri, Anasuya, Chandramati.
Her film career began with the Chandramati character in Harischandra (1935) of Star combines.
She acted in the title role of Kannagi in Tamil and in Palnati Yudham as Nayakuralu Nagamma opposite Govindarajula Subba Rao. She acted in Ashok Kumar (1941) as Queen opposite another great actor, Chittor V. Nagaiah.
She acted together P. U. Chinnappa in many movies, such as Kannagi, Mahamaya, Harischandra and Tulasi Jalandhar. They established "Raja Rajeswari Films" and produced about 30 films, including Sumati, Padhuka Pattabhishekam, Saudamani, Peda Raitu, Lakshmi, Sri Krishna Tulabharam, Sati Sakkubhai, and Sati Anasuya.
Their Navajeevanam (1949) was awarded as the best film by Combined Madras state.
She died at the age of 51 on 7 May 1964 at a nursing home in Chennai.
