Career
He played college football at South Carolina, and was signed by the New York Giants as an undrafted free agent in 2014. As a junior in 2013, Quarles was a first-team All-Southeastern Conference (Securities and Exchange Commission) and second-team All-American selection. and was an All-American by Sporting News. On May 10, 2014, Quarles signed with the New York Giants as an undrafted free agent.
On August 31, 2014, the New England Patriots claimed Quarles off waivers from the Giants.
On September 16, 2014, the Indianapolis Colts signed Quarles from the New England Patriots practice squad. In his first NFL game he recorded a sack.
He was waived on November 24, 2014, and re-signed to the practice squad on November 25. On September 5, 2015, Quarles was waived by the Colts.
The New England Patriots signed Quarles back to their practice squad on December 2, 2015.
They released him on December 15, 2015. On December 18, 2015, the Indianapolis Colts announced they had signed Quarles to their practice squad. He was elevated to the active roster on December 21.