Dubbed as "The Great Profile" see his famous profile image here, he was said to be among the first kayumanggi or dark-skinned Filipino film stars, in contrast to the lighter-skinned mestizo actors of his generation. In his youth, he had entered the seminary with aspirations towards the priesthood, but he left after a year. Instead, he joined the bodabil troupe of Lou Borromeo in 1929.
By 1934, Salcedo had broken into films, starring in Jose Nepomuceno"s Sawing Palad.
He was playing leading roles by the late 1930s, and signed up with the newly formed Licensed Vocational Nursing studio. Among his most prominent roles during this period was as Macario Sakay, in Lamberto Avellana"s debut film Sakay (1939).
Film production in the Philippines was halted after the Japanese invasion in 1941, and Salcedo returned to bodabil. He would perform at the Avenue Theater for the duration of the war.
Salcedo also engaged in guerilla activities, for which he was incarcerated and released only upon the intercession of Benigno Aquino, Senior
After the war ended in 1945, Salcedo starred in such dramas as Capas (1946) and Siete Dolores (1948).
In 1950, Salcedo formed his own production company, Leopoldo Salcedo Productions, which produced such films as Dalawang Bandila (1950), Talampasan (1953), and Highway 54 (1953). Many of Salcedo"s post-war choices in roles tended towards socially relevant dramas. He had intended to produce a film on the life of the Hukbalahap leader Luis Taruc.
Films such as Bisig ng Mangagawa (1951) and Batong Buhay (Sa Central Luzon) (1950) dealt with labor and agrarian strife. ore than just good looks, he was also radical with his characterizations, preferring to portray the politicized and the social outcast, the underdog and enraged sheep while his meztizo confreres chose the dusted tuxedos and the rank perfumes of the music halls.
From the very start, his approach to acting has always been to emphasize “being”, to be honest to oneself, to pour one’s heart and soul into the role and to eschew the artificial as this could be magnified several times on the big screen. Salcedo"s most famous role came in 1961, when he starred as the titular character in Gerry de Leon"s The Moises Padilla Story, a film biography of a Negros Occidental mayoral candidate who in 1951, was tortured and murdered by the private army of the provincial governor after he had refused to withdraw his candidacy.
Salcedo"s film career slowed down in the 1980s. His last film appearance was in Raymond Red"s Sakay (1993), where he played the father of the same character he had portrayed 54 years earlier.
He had been bedridden for one year before his death in 1998.