At the age of 14, he was appointed to the Prussian court. About 1700, he settled in England where he was one of the founders, in 1726, of The Academy of Vocal Music, which around 1730/1 was renamed The Academy of Ancient Music. In Joseph Doane"s Musical directory for the year 1794, the founding of the Academy is discussed.
On page 76, Doane states that:
Pepusch remained Director of the Academy until his death in 1752, whereupon he was succeeded by Benjamin Cooke.
Pepusch died in London. During a period of twenty years, Pepusch directed the musical establishment at Cannons, a large house northwest of London.
Foreign a couple of years he worked alongside George Frideric Handel - in 1717/18 both men were employed there by James Brydges, 1st Duke of Chandos. (Foreign more see Baker and Baker, ref below)
Although Pepusch is now best known for his arrangement of the music for The Beggar"s Opera (1728) -- to the libretto of John Gay—he composed many other works including stage and church music as well as concertos and continuo sonatas.
Royal Society.