Career
Nicole originally started off as a schemer but as her popularity increased, her character became one of the show"s major heroines in a romance with attorney Adam Drake (Donald May). When she first left the show, the character was presumed dead, but after a year"s hiatus, returned. During that time, the character of Adam was brutally murdered and Nicole was paired with handsome new doctor Miles Cavanaugh (Joel Crothers).
She was then replaced by actress Jayne Bentzen, almost twenty years her junior.
Between her two stints on The Edge of Night, she played Maude Lassiter Palmer on the short-lived nighttime show Beacon Hill. McGuire took over the part of Kate McCleary, a matriarchal role which had earlier been played by the older Jo Henderson.
She later played Judith Sheffield, the socialite mother of a gay teen played by Ben Jorgensen, on the soap opera All My Children. She also filled in for Eileen Fulton as Lisa on As the World Turns a number of times during the early 1990s and also played Selena, a madame, on Guiding Light for a brief time in 1993.
She has appeared on stage as M"Lynn in off-Broadway"s Steel Magnolias, as Irene Livingston in the Jewish Repertory Theatre"s Light Up the Sky, and on Broadway in Cyrano de Bergerac (Cassandace), The Miser (Marianne), Mixed Emotions (understudying the character Christine Millman) and Garden District (understudying the characters Mrs Venable, Mission Foxhill and Grace).