Career
De los Santos started his career playing with Cerro in 2011. He made his debut on 20 February 2011 against Defensor Sporting. On June 19, 2013 he signed for Club Nacional de Football.
Under-20
During 2009, De los Santos played with the Uruguayan national under-20 football team at the 2011 Fédération internationale de football association U-20 World Cup in Colombia.
Under-22
In 2011, he was named to participate in the Uruguay national football team under-22 squad for the 2011 Pan American Games.