Career
From 1489 to 1494, she was the Duchess consort of Milan, and from 1499 to 1524 the suo jure Duchess of Bari and Princess of Rossano. Francesco, who was taken to France by the French King Louis XII in 1499,
Bona, who married King Sigismund I of Poland,
Ippolita Maria. Isabella also outlived Francesco, who was killed in 1512 by falling from his horse.
In 2012, anthropologists excavated the body of Isabella of Aragon, and concluded that she had syphilis.
Her teeth had a high level of mercury, which was used (ineffectively) to treat syphilis, and had given a black color to the tooth enamel, most of which had been removed by abrading. They concluded that she was poisoned by her own medicine.