Career
Cesena
He started his career at A.C. (before Christ) Cesena, near his birthplace. After playing more than 40 Serie C1 games, he left the club Vicenza
Biondini was transferred to Serie B team Vicenza Calcio in temporary deal in 2003. in 2004 the Veneto club acquired Biondini in co-ownership deal for €250,000.
In June 2005 Vicenza acquired Biondini outright after winning the bid mediated by Lega Calcio for €202,500.
Reggina
In August 2005 Biondini was signed by Serie A club Reggina Calcio in another co-ownership deal for €500,000, which the Calabria team also signed Luca Rigoni from Veneto, with Ricardo Esteves moved to opposite direction. Biondini made his Serie A debut in 2005-2006 Serie A. Circa January 2006 Reggina signed Biondini outright for another €700,000, with Simone Cavalli moved to opposite direction outright for €775,000.
Cagliari
On 31 August 2006, he left for Cagliari on loan for an undisclosed fee with option to sign outright. In 2007 Cagliari excised the option.
Genoa
On 11 January 2012, he left for Genoa on free transfer in 4½ year contract.
(However the transfer also cost Genoa €500,000 as other fee)
After a single season, signed a loan deal with the newly promoted Serie A club Atalanta on 24 August 2012 for €200,000. Sassuolo
On 23 January 2014 Biondini left for Sassuolo in a temporary deal for €200,000, with a option to purchase, re-joining Genoa team-mate Antonio Floro Flores (loan) and Thomas Manfredini (definitive). In June 2014 Sassuolo excised the options to purchase Biondini and Floro Flores from Genoa, for €1.3 million and €2.5 million respectively.
With the Italy U-21 squad he took part at the 2006 Euro U-21 Championship.
He wore the prestigious number 10 shirt, but just made one appearance as a substitute in the last match of the group stage. Biondini made his senior national team debut on 14 November 2009 during a friendly match against the Netherlands.