He was sometimes known as "The Junk Manitoba", but better known as "Steady Eddie", a nickname later given to Eddie Murray. A left-hander, Lopat made his Major League pitching debut on April 30, 1944, playing for the Chicago White Sox. He was traded to the New York Yankees on February 24, 1948 for Aaron Robinson, Bill Wight, and Fred Bradley.
From 1948 to 1953 he was the third of the "Big Three" of the Yankees" pitching staff, together with Allie Reynolds and Vic Raschi.
He pitched in the All-Star Game in 1951 for the American League. Lopat managed the Triple-A Richmond Virginians for the Yankees in the late 1950s, and in 1960 served one season as the Yankees" pitching coach before holding the same post with the Minnesota Twins in 1961 and the Kansas City Athletics in 1962.
In 1963 Lopat was tapped to manage the Athletics and continued in this role until June 11, 1964. His Major League managerial record was 90-124 (421).
Lopat stayed on as a senior front office aide to team owner Charlie Finley until the club moved to Oakland after the 1967 season.
He then scouted for the Montreal Expos during their early years in Major League Baseball. In 1978, Eddie Lopat was inducted into the National Polish-American Sports Hall of Fame He died at his son"s home in Darien, Connecticut, on June 15, 1992. Lopat pitched for five victorious Yankees teams in the World Series during his career, in 1949-1953.