Career
Born in Güstrow, she was the tenth of eleven children born from the marriage of Gustav Adolph, Duke of Mecklenburg-Güstrow and Magdalene Sibylle of Holstein-Gottorp. In Güstrow on 29 March 1692, Elisabeth married Prince Henry of Saxe-Merseburg, fourth surviving son of Duke Christian I. Two years later (1694), Henry received the town of Spremberg as his appanage, and took his residence there. The marriage produced three children, of whom only one survive adulthood:
Maurice, Hereditary Prince of Saxe-Spremberg (Spremberg, 29 October 1694 - Spremberg, 11 April 1695).
Christiana Fredericka (Spremberg, 17 May 1697 - Spremberg, 21 August 1722).
Gustava Magdalena (Spremberg, 2 October 1699 - Spremberg, 3 October 1699). She was buried in Merseburg Cathedral.